Cefiderocol, CAS 1225208-94-5

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Cefiderocol, CAS 1225208-94-5\, Stock 327g, Assay 99.5%, White powder, Water 0.17%, Single Impurity 0.5%.


Cefiderocol
Cefiderocol (free base), also known as S-649266, is a potent siderophore cephalosporin antibiotic with a catechol moiety on the 3-position side chain. S-649266 shows potent in vitro activity against the non-fermenting Gram-negative bacteria Acinetobacter baumannii, Pseudomonas aeruginosa and Stenotrophomonas maltophilia, including MDR strains such as carbapenem-resistant A. baumannii and metallo-β-lactamase-producing P. aeruginosa. S-649266 showed potent in vitro activities against A. baumannii producing carbapenemases such as OXA-type β-lactamases, and P. aeruginosa producing metallo-β-lactamases such as IMP type and VIM type. FDA approved this drug in 11/14/2019 To treat patients with complicated urinary tract infections who have limited or no alternative treatment options


Product Details:
Name: Cefiderocol free base

CAS#: 1225208-94-5 (free base)

Chemical Formula: C30H34ClN7O10S2

Exact Mass: 751.1497

Molecular Weight: 752.21

Elemental Analysis: C, 47.90; H, 4.56; Cl, 4.71; N, 13.03; O, 21.27; S, 8.52



Specification:
Synonym: S-649266; S 649266; S649266; GSK2696266D; GSK-2696266D; GSK 2696266D; S-649266D; S 649266D; S649266D; Cefiderocol; Fetroja.

IUPAC/Chemical Name: (6R,7R)-7-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetamido]-3-({1-[2-(2-chloro-3,4-dihydroxybenzamido)ethyl]pyrrolidin-1-ium-1-yl}methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

InChi Key: DBPPRLRVDVJOCL-FQRUVTKNSA-N

InChi Code: InChI=1S/C30H34ClN7O10S2/c1-30(2,28(46)47)48-36-19(16-13-50-29(32)34-16)24(42)35-20-25(43)37-21(27(44)45)14(12-49-26(20)37)11-38(8-3-4-9-38)10-7-33-23(41)15-5-6-17(39)22(40)18(15)31/h5-6,13,20,26H,3-4,7-12H2,1-2H3,(H7-,32,33,34,35,36,39,40,41,42,44,45,46,47)/t20-,26-/m1/s1

SMILES Code: OC(C(O)=C1Cl)=CC=C1C(NCC[N+]2(CCCC2)CC3=C(C([O-])=O)N4C([C@H]([C@]4(SC3)[H])NC(/C(C5=CSC(N)=N5)=N\OC(C(O)=O)(C)C)=O)=O)=O

Appearance: Solid powder

Purity: >95% (or refer to the Certificate of Analysis5

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001